Save through Siklos® Savings Programs

If you have commercial insurance, there are two easy ways to pay as little as $0 for your child’s Siklos® prescription:

Learn more about Siklos® savings options

Option 1: If you wish to fill your child’s prescription at a local retail pharmacy.

Simply present an eligible Siklos® prescription at a participating Relay Health pharmacy and your Siklos® eVoucher savings will be applied automatically —no coupon necessary.

Find a Relay Health pharmacy near you

Option 2: If you wish to fill your child’s prescription through a mail order pharmacy.

Ask your child’s healthcare professional to fax, call or e-prescribe Siklos® through the ProCare Pharmacy Care Siklos At Home® program. In addition to saving on your child’s prescription costs, the Siklos At Home® program also offers the convenience of free home delivery (minimum purchase of $99), on-staff pharmacists to answer your product questions, assistance with insurance benefit verification and monthly refill reminders.

Download Siklos At Home® Patient Instructions

Questions? Call ProCare Pharmacy Care at 1-866-610-7787

If you do not have commercial insurance or your commercial insurance does not cover Siklos® (i.e. cash payers):

  • Siklos® 100 mg tablets: pay as little as $99 for 60 tablets or $149 for 90 tablets
  • Siklos® 1,000 mg tablets: pay as little as $16.50/tablet

Patient Assistance Program: When affording your child’s Siklos® prescription is difficult

Medunik USA believes that every patient with sickle cell disease has the right to access safe and effective medication. We understand that, at times, the cost of prescription medications can be a challenge. That is why we created our Patient Assistance Program. If you cannot afford your child’s Siklos® prescription, your child may be eligible to receive Siklos® at no charge through our Patient Assistance Program.

To apply, please follow these steps:

  1. Download and follow the instructions on this Enrollment Application.
  2. Complete sections marked step 1 and step 2
  3. Have your child’s healthcare provider complete sections marked step 3 and step 4
  4. Submit proof of income, as instructed on the form, under PATIENT ASSISTANCE PROGRAM INSTRUCTIONS FOR SIKLOS®
  5. Fax page 1 of the form to 844-375-3010

Indication and important safety information

Siklos® (hydroxyurea) tablets, for oral use


Siklos® is a prescription medicine that is used to reduce the frequency of painful crises and reduce the need for blood transfusions in children, 2 years of age and older, with sickle cell anemia with recurrent moderate to severe painful crises.

It is not known if Siklos® is safe and effective in children less than 2 years of age.



See full prescribing information for complete Boxed Warning.

  • Low blood cell counts are common with Siklos®, including low red blood cells, white blood cells, and platelets, and can be severe and life threatening. If your white blood cell count becomes very low, you are at increased risk for infection. Your healthcare provider will check your blood cell counts before and during treatment with Siklos®. Your healthcare provider may change your dose or tell you to stop taking Siklos® if you have low blood cell counts. Tell your healthcare provider right away if you get any of the following symptoms: fever or chills; shortness of breath; body aches; unusual headache; feeling very tired; bleeding or unexplained bruising.

  • Cancer. Some people have developed cancer, such as leukemia and skin cancer, after taking Siklos® for a long time. Your healthcare provider will check you for cancer. You should protect your skin from the sun using sunblock, hats, and sun-protective clothing.


  • Siklos® can harm your unborn baby.
  • For females taking Siklos® who can become pregnant:
    • You should talk with your healthcare provider about the risks of Siklos® to your unborn baby.
    • You should use effective birth control during treatment with Siklos® and for at least 6 months after treatment with Siklos®.
    • Your healthcare provider will perform a pregnancy test before you start treatment with Siklos®. Tell your healthcare provider right away if you become pregnant or think you may be pregnant.
    • For males taking Siklos®. Siklos® can affect your sperm. If you have a female sexual partner who can become pregnant, you should use effective birth control during treatment with Siklos® and for at least 6 months after treatment.
  • Siklos® may cause fertility problems in males. Talk to your healthcare provider if this is a concern for you.


Do not take Siklos® if you are allergic to hydroxyurea or any of the ingredients in Siklos®. See the Medication Guide for a list of the ingredients in Siklos®.


Tell your healthcare provider about all of your medical conditions, including if you:

  • have kidney problems or are receiving hemodialysis
  • have liver problems
  • have human immunodeficiency virus (HIV) or take HIV medicines. Taking Siklos® with certain HIV medicines can cause serious reactions and may lead to death.
  • have increased levels of uric acid in your blood (hyperuricemia)
  • have a history of receiving interferon therapy or are currently receiving interferon therapy
  • have leg wounds or ulcers
  • plan to receive any vaccinations. You should not receive “live vaccines” during treatment with Siklos®.
  • are pregnant or plan to become pregnant. See “What is the most important information I should know about Siklos®?”
  • are breastfeeding or plan to breastfeed. It is not known if Siklos® can pass into your breast milk. Do not breastfeed during treatment with Siklos®.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.


Siklos® may cause serious side effects, including:

See “What is the most important information I should know about Siklos®?”

  • Skin ulcers, including leg ulcers have happened in people who take Siklos®. This has happened most often in people who receive interferon therapy or have a history of interferon therapy. Your healthcare provider will decrease your dose or stop treatment with Siklos® if you develop any skin ulcers.
  • Enlarged red blood cells (macrocytosis). Macrocytosis is common in people who take Siklos® and can make it difficult to detect a decrease of folic acid. Your healthcare provider may prescribe a folic acid supplement for you.

The most common side effects of Siklos® include:

  • Infections
  • Headache
  • Fever
  • Skin problems (e.g., skin reactions, dry skin, changes in skin and nail color)
  • Stomach and intestine (gastrointestinal) problems (e.g. nausea, constipation)
  • Decrease in vitamin D
  • Weight gain

These are not all the possible side effects of Siklos®.

You are encouraged to report negative side effects of prescription drugs to the FDA at, or 1-800-FDA-1088.

Please read the Full Prescribing Information, including Boxed Warning, Medication Guide and Instructions for Use, at

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